Positive Bias in Mycophenolic Acid Concentrations Determined by the CEDIA Assay Compared to HPLC-UV Method: Is CEDIA Assay Suitable for Therapeutic Drug Monitoring of Mycophenolic Acid?
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چکیده
منابع مشابه
Diagnostic and Therapeutic Corner Therapeutic Drug Monitoring of Mycophenolic Acid
M ycophenolic acid (MPA)-based therapies are widely used in combination with calcineurin inhibitors as maintenance immunosuppression for kidney transplant recipients (1). The two MPA therapies used in clinical transplantation are mycophenolate mofetil (MMF [brand name CellCept, Roche Pharmaceuticals, Nutley, NJ]) and mycophenolate sodium (MPS [brand name Myfortic, Norvartis Pharmaceuticals, Nut...
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The CEDIA dau Benzodiazepine assay has been reformulated to include online hydrolysis of urinary benzodiazepine glucuronide conjugates. The new antibody possesses enhanced cross-reactivities toward the low-dose benzodiazepines, which are excreted at low urinary drug-metabolite concentrations. The screening method was evaluated using lorazepam as the probe benzodiazepine. Four subjects each cons...
متن کاملSimple and Sensitive High-Performance Liquid Chromatography (HPLC) Method with UV Detection for Mycophenolic Acid Assay in Human Plasma. Application to a Bioequivalence Study.
PURPOSE A simple and available reversed-phase high performance liquid chromatography (HPLC) method with UV detection has been developed and validated for mycophenolic acid (MPA) assay in human plasma. METHODS MPA was extracted from plasma with protein precipitation method by acetonitrile: percholeric acid: methanol (75:5:20 v/v/v). The drug separation was achieved using a C8 analytical column...
متن کاملTherapeutic drug monitoring for mycophenolic acid in patients with autoimmune diseases.
Mycophenolate mofetil (MMF, CellCept R © ) has become the most frequently used immunosuppressive drug in kidney transplant recipients [1]. Since its approval for the prevention of acute rejection after kidney transplantation in 1995 in the USA and in 1996 in Europe, the use of azathioprine has been rapidly diminishing, giving way to the use of MMF. A second formulation of mycophenolic acid (MPA...
متن کاملNonlinear relationship between mycophenolate mofetil dose and mycophenolic acid exposure: implications for therapeutic drug monitoring.
BACKGROUND AND OBJECTIVES Mycophenolate mofetil (MMF) is an immunosuppressive drug used in renal transplant patients. Upon oral administration it is hydrolyzed to the active agent mycophenolic acid (MPA). In renal transplant recipients, MMF therapy is optimal when the area under the curve of MPA is 30 to 60 mg·h/L. When MMF doses are adjusted, a linear relationship between dose and MPA exposure...
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ژورنال
عنوان ژورنال: Journal of Clinical Laboratory Analysis
سال: 2013
ISSN: 0887-8013
DOI: 10.1002/jcla.21565